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publications

Challenges in IBD Research: Preclinical Human IBD Mechanisms

Pizarro TT, Stappenbeck TS, Florian R, Rosen MJ, Colombel JF, Donowitz M, Towne J, Mazmanian SK, Faith JJ, Hodin RA, Garrett WS, Fichera A, Poritz LS, Cortes CJ, Shtraizent N, Honig G, Snapper SB, Hurtado-Lorenzo A, Salzman NH, Chang EB Inflammatory Bowel Disease (2019) 25 (S2) S5-S12 doi: 10.1093/ibd/izz075


Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice

Sharon G, Cruz NJ, Kang DW, Gandal MJ, Wang B, Kim YM, Zink EM, Casey CP, Taylon BC, Lane CJ, Bramer LM, Isern NG, Hoyt DW, Noecker C, Sweredoski MJ, Moradian A, Borenstein E, Jansson JK, Knight R, Metz TO, Lois C, Geschwind DH, Krajmalnik-Brown R, Mazmanian SK, Cell. (2019) 5:004 https://doi.org/10.1016/j.cell.2019.05.004


Microbiome–microglia connections via the gut–brain axis

Abdel-Haq R, Schlachetzki JCM, Glass CK, Mazmanian SK JEM. 2018 Nov doi: 10.1084/jem.20180794


The Protective Role of Bacteroides fragilis in a Murine Model of Colitis-Associated Colorectal Cancer

Lee YK, Mehrabian P, Boyajian B, Wu WL, Selicha J, Vonderfecht S, Mazmanian SK. mSphere. 2018 Nov doi: 10.1128/mSphere.00587-18


A gut microbial factor modulates locomotor behaviour in Drosophila

Scretter CE, Vielmetter J, Bartos I, Marka Z, Marka S, Argade S, Mazmanian SK Nature. 2018 Oct doi: 10.1038/s41586-018-0634-9


Multiple sclerosis-associated changes in the composition and immune functions of spore-forming bacteria

Cekanaviciute E, Probstel AK, Thomann A, Runia TF, Casaccia P, Sand IK, Crabtree E, Singh S, Morrissey J, Barba P, Gomez R, Knight R, Mazmanian SK, Graves J, Cree BAC, Zamvil SS, Baranzini SE mSystems (2018) Jun 3:6 https://doi.org/10 .1128/mSystems.00083-18.


Gut microbiota utilize immunoglobulin A for mucosal colonization

Donaldson GP, Ladinsky MS, Yu KB, Sanders JG, Yoo BB, Chou WC, Conner ME, Earl AM, Knight R, Bjorkman PJ, Mazmanian SK Science. 2018 May Abstract / Full Text / Reprint


Cultivating a Relationship with Gut Bacteria

Schretter CE and Mazmanian SK. (2018) Cell Metabolism. 27 (2). pp. 267-268. doi: 10.1016/j.cmet.2018.01.010


Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

Cekanaiciute E, Yoo BB, Runia TF, Debelius JW, Singh S, Nelson CA, Kanner R, Bencosme Y, Lee YK, Hauser SL, Crabtree-Hartman E, Sand IK, Gacias M, Zhu Y, Casaccia P, Cree BAC, Knight R, Mazmanian SK, Baranzini SE. Proc Natl Acad Sci U S A. 2017 Aug. doi: 10.1073/pnas.1711235114


Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

Chan KY, Jang MJ, Yoo BB, Greenbaum A, Ravi N, Wu W, Sanchez-Guardado L, Lois C, Mazmanian SK, Deverman BE, Gradinaru V. Nature Neuroscience. 2017 Jun. doi:10.1038/nn.4593


The Microbiome Activates CD4 T-cell-mediated Immunity to Compensate for Increased Intestinal Permeability

Edelblum KL, Sharon G, Gurminder S, Odenwald MA, Sailer A, Cao S, Ravens S, Thomsen I, Bissati KE, McLeod R, Dong C, Gurbuxani S, Prinz I, Mazmanian SK, Turner JR. Cellular and Molecular Gastroenterology and Hepatology. 2017 Jun. https://doi.org/10.1016/j.jcmgh.2017.06.001


Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

Sampson, TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, Challis C, Schretter CE, Rocha S, Gradinaru V, Chesselet M-F, Keshavarzian A, Shannon KM, Krajmalnik-Brown R, Wittung-Stafshede P, Knight R, Mazmanian SK. Cell. 2016 Dec 1. https://doi.org/10.1016/j.cell.2016.11.018


The Placental Interleukin-6 Signaling Controls Fetal Brain Development and Behavior

Wu WL, Hsiao EY, Yan Z, Mazmanian SK, Patterson PH. Brain Behavior and Immunity. 2016 Nov 9. doi: https://doi.org/10.1016/j.bbi.2016.11.007


The Central Nervous System and the Gut Microbiome

Sharon G, Sampson TR, Geschwind DH, and Mazmanian SK. Cell. 2016 Nov. https://doi.org/10.1016/j.cell.2016.10.027


Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

Chu H, Khosravi A, Kusumawardhani IK, Kwon AHK, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan ST, Xavier RJ, Ernst PB, Green DR. McGovern DPB, Virgin HW, Mazmanian SK. Science. 2016 May 5. https://doi.org/10.1126/science.aad9948


Gut biogeography of the bacterial microbiota

Donaldson GP, Lee SM, Mazmanian SK. Nature Reviews Microbiology. 2015 Oct 26. https://doi.org/10.1038/nrmicro3552 Review.


Control of Brain Development, Function, and Behavior by the Microbiome

Sampson TR, Mazmanian SK. Cell Host Microbe. 2015 May 13;17(5):565-576. https://doi.org/10.1016/j.chom.2015.04.011 Review.


Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis.

Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, Nagler CR, Ismagilov RF, Mazmanian SK, Hsiao EY. Cell. 2015 Apr 9;161(2):264-76. https://doi.org/10.1016/j.cell.2015.02.047


Maternal Immune Activation Perturbs Fetal Brain Development and Adult Behaviors Through Placental Trophoblast IL-6 Activation.

Wu W, Hsiao EY, Yan Z, Mazmanian SK, Patterson PH. Schizophrenia Bulletin. 2015 Mar 1;41(supp 1):S1-S341. doi:10.1093/schbul/sbv010.


Specialized metabolites from the microbiome in health and disease.

Sharon G, Garg N, Debelius J, Knight R, Dorrestein PC, Mazmanian SK. Cell Metab. 2014 Nov 4;20(5):719-30. https://doi.org/10.1016/j.cmet.2014.10.016. Epub 2014 Nov 4.


Gut microbes and the brain: paradigm shift in neuroscience.

Mayer EA, Knight R, Mazmanian SK, Cryan JF, Tillisch K. J Neurosci. 2014 Nov 12;34(46):15490-6. https://doi.org/10.1523/JNEUROSCI.3299-14.2014 Review.


Commensal bacteria protect against food allergen sensitization.

Stefka AT, Feehley T, Tripathi P, Qiu J, McCoy K, Mazmanian SK, Tjota MY, Seo GY, Cao S, Theriault BR, Antonopoulos DA, Zhou L, Chang EB, Fu YX, Nagler CR. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13145-50. https://doi.org/10.1073/pnas.1412008111. Epub 2014 Aug 25.


The MS Microbiome Consortium (MSMC): an academic multi-disciplinary collaborative effort to elucidate the role of the gut microbiota in MS.

Baranzini SE, Katz-Sand I, Mazmanian SK, Becosme Y, London J, Farber R, Kanner R, Gomez R, Cree BA, Knight R, Casaccia P. Multiple Sclerosis Journal. (2014) 20 (S1). p. 339. doi: 10.1177/1352458514547846 *


Finding the Missing Links among Metabolites, Microbes, and the Host.

Dorrestein PC, Mazmanian SK, Knight R. Immunity. 2014 Jun 19;40(6):824-832. https://doi.org/10.1016/j.immuni.2014.05.015. Review.


Gut microbiota promote hematopoiesis to control bacterial infection.

Khosravi A, Yáñez A, Price JG, Chow A, Merad M, Goodridge HS, Mazmanian SK. Cell Host Microbe. 2014 Mar 12;15(3):374-81. https://doi.org/10.1016/j.chom.2014.02.006


Identification of secreted bacterial proteins by noncanonical amino acid tagging.

Mahdavi A, Szychowski J, Ngo JT, Sweredoski MJ, Graham RL, Hess S, Schneewind O, Mazmanian SK, Tirrell DA. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):433-8. https://doi.org/10.1073/pnas.1301740111. Epub 2013 Dec 17.


Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.

Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH,Mazmanian SK. Cell. 2013 Dec 19;155(7):1451-63. doi: https://doi.org/10.1016/j.cell.2013.11.024. Epub 2013 Dec 5.


Bacterial colonization factors control specificity and stability of the gut microbiota.

Lee SM, Donaldson GP, Mikulski Z, Boyajian S, Ley K, Mazmanian SK. Nature. 2013 Sep 19;501(7467):426-9. https://doi.org/10.1038/nature12447. Epub 2013 Aug 18.


Disruption of the gut microbiome as a risk factor for microbial infections.

Khosravi A, Mazmanian SK. Curr Opin Microbiol. 2013 Apr;16(2):221-7. https://doi.org/10.1016/j.mib.2013.03.009. Epub 2013 Apr 15. Review.


Animals in a bacterial world, a new imperative for the life sciences.

McFall-Ngai M, Hadfield MG, Bosch TC, Carey HV, Domazet-Lošo T, Douglas AE, Dubilier N, Eberl G, Fukami T, Gilbert SF, Hentschel U, King N, Kjelleberg S, Knoll AH, Kremer N, Mazmanian SK, Metcalf JL, Nealson K, Pierce NE, Rawls JF, Reid A, Ruby EG, Rumpho M, Sanders JG, Tautz D, Wernegreen JJ. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3229-36. https://doi.org/10.1073/pnas.1218525110. Epub 2013 Feb 7. Review.


A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis.

Noval Rivas M, Burton OT, Wise P, Zhang YQ, Hobson SA, Garcia Lloret M, Chehoud C, Kuczynski J, DeSantis T, Warrington J, Hyde ER, Petrosino JF, Gerber GK, Bry L, Oettgen HC, Mazmanian SK, Chatila TA. J Allergy Clin Immunol. 2013 Jan;131(1):201-12. https://doi.org/10.1016/j.jaci.2012.10.026. Epub 2012 Nov 30.


Outer membrane vesicles of a human commensal mediate immune regulation and disease protection.

Shen Y, Giardino Torchia ML, Lawson GW, Karp CL, Ashwell JD, Mazmanian SK. Cell Host Microbe. 2012 Oct 18;12(4):509-20. https://doi.org/10.1016/j.chom.2012.08.004. Epub 2012 Sep 20.


Modeling an autism risk factor in mice leads to permanent immune dysregulation.

Hsiao EY, McBride SW, Chow J, Mazmanian SK, Patterson PH. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12776-81. https://doi.org/10.1073/pnas.1202556109. Epub 2012 Jul 16.


Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice.

Wingender G, Stepniak D, Krebs P, Lin L, McBride S, Wei B, Braun J, Mazmanian SK, Kronenberg M. Gastroenterology. 2012 Aug;143(2):418-28. https://doi.org/10.1053/j.gastro.2012.04.017. Epub 2012 Apr 19.


Breathe easy: microbes protect from allergies.

Khosravi A, Mazmanian SK. Nature Medicine. 2012 Apr 5;18(4):492-4. https://doi.org/10.1038/nm.2723


Pathobionts of the gastrointestinal microbiota and inflammatory disease.

Chow J, Tang H, Mazmanian SK. Curr Opin Immunol. 2011 Aug;23(4):473-80. https://doi.org/10.1016/j.coi.2011.07.010. Epub 2011 Aug 17. Review.


The human commensal Bacteroides fragilis binds intestinal mucin.

Huang JY, Lee SM, Mazmanian SK. Anaerobe. 2011 Aug;17(4):137-41. doi: 10.1016/j.anaerobe.2011.05.017. Epub 2011 Jun 2.


The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota.

Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, Mazmanian SK. Science. 2011 May 20;332(6032):974-7.
https://doi.org/10.1126/science.1206095. Epub 2011 Apr 21.


Host-bacterial symbiosis in health and disease.

Chow J, Lee SM, Shen Y, Khosravi A, Mazmanian SK. Adv Immunol. 2010;107:243-74. https://doi.org/10.1016/B978-0-12-381300-8.00008-3. Review.


Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis.

Lee YK, Menezes JS, Umesaki Y, Mazmanian SK. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4615-22. https://doi.org/10.1073/pnas.1000082107. Epub 2010 Jul 26.


Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota.

Round JL, Mazmanian SK. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12204-9. https://doi.org/10.1073/pnas.0909122107. Epub 2010 Jun 21.


Coordination of tolerogenic immune responses by the commensal microbiota.

Round JL, O'Connell RM, Mazmanian SK. J Autoimmun. 2010 May;34(3):J220-5. https://doi.org/10.1016/j.jaut.2009.11.007. Epub 2009 Dec 6. Review.


The gut microbiota shapes intestinal immune responses during health and disease.

Round JL, Mazmanian SK. Nat Rev Immunol. 2009 May;9(5):313-23. https://doi.org/10.1038/nri2515. Review. Erratum in: Nat Rev Immunol. 2009 Aug;9(8):600.


A microbial symbiosis factor prevents intestinal inflammatory disease.

Mazmanian SK, Round JL, Kasper DL. Nature. 2008 May 29;453(7195):620-5. https://doi.org/10.1038/nature07008.


Capsular polysaccharides of symbiotic bacteria modulate immune responses during experimental colitis.

Mazmanian SK. J Pediatr Gastroenterol Nutr. 2008 Apr;46 Suppl 1:E11-2. 10.1097/01.mpg.0000313824.70971.a7. Review. No abstract available.


Regulation of surface architecture by symbiotic bacteria mediates host colonization.

Liu CH, Lee SM, Vanlare JM, Kasper DL, Mazmanian SK. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3951-6. https://doi.org/10.1073/pnas.0709266105. Epub 2008 Mar 4.


Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system.

Garrett WS, Lord GM, Punit S, Lugo-Villarino G, Mazmanian SK, Ito S, Glickman JN, Glimcher LH. Cell. 2007 Oct 5;131(1):33-45. https://doi.org/10.1016/j.cell.2007.08.017


The love-hate relationship between bacterial polysaccharides and the host immune system.

Mazmanian SK, Kasper DL. Nat Rev Immunol. 2006 Nov;6(11):849-58. Epub 2006 Oct 6. Review. https://doi.org/10.1038/nri1956


Structures of sortase B from Staphylococcus aureus and Bacillus anthracis reveal catalytic amino acid triad in the active site.

Zhang R, Wu R, Joachimiak G, Mazmanian SK, Missiakas DM, Gornicki P, Schneewind O, Joachimiak A. Structure. 2004 Jul;12(7):1147-56. https://doi.org/10.1016/j.str.2004.06.001


The role of Staphylococcus aureus sortase A and sortase B in murine arthritis.

Jonsson IM, Mazmanian SK, Schneewind O, Bremell T, Tarkowski A. Microbes Infect. 2003 Jul;5(9):775-80. https://doi.org/10.1016/S1286-4579(03)00143-6


Passage of heme-iron across the envelope of Staphylococcus aureus.

Mazmanian SK, Skaar EP, Gaspar AH, Humayun M, Gornicki P, Jelenska J, Joachmiak A, Missiakas DM, Schneewind O. Science. 2003 Feb 7;299(5608):906-9. https://doi.org/10.1126/science.1081147


On the role of Staphylococcus aureus sortase and sortase-catalyzed surface protein anchoring in murine septic arthritis.

Jonsson IM, Mazmanian SK, Schneewind O, Verdrengh M, Bremell T, Tarkowski A. J Infect Dis. 2002 May 15;185(10):1417-24. Epub 2002 Apr 22. https://doi.org/10.1086/340503


Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence.

Bierne H, Mazmanian SK, Trost M, Pucciarelli MG, Liu G, Dehoux P, Jänsch L, Garcia-del Portillo F, Schneewind O, Cossart P; European Listeria Genome Consortium. Mol Microbiol. 2002 Feb;43(4):869-81. https://doi.org/10.1046/j.1365-2958.2002.02798.x


An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis.

Mazmanian SK, Ton-That H, Su K, Schneewind O. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2293-8. Epub 2002 Feb 5. https://doi.org/10.1073/pnas.032523999


Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall.

Mazmanian SK, Liu G, Ton-That H, Schneewind O. Science. 1999 Jul 30;285(5428):760-3.