Sarkis Mazmanian Lab Homepage
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Publications
Publications
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Publications
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2024
- Griffiths, Jessica A.;Yoo, Bryan B. et al. (2024) Peripheral neuronal activation shapes the microbiome and alters gut physiologyISSN 2211-1247PMCID PMC11132177
2023
- Nemet, Ina;Funabashi, Masanori et al. (2023) Microbe-derived uremic solutes enhance thrombosis potential in the hostISSN 2150-7511
- Morton, James T.;Jin, Dong-Min et al. (2023) Multi-level analysis of the gut–brain axis shows autism spectrum disorder-associated molecular and microbial profilesISSN 1097-6256PMCID PMC10322709
- Boktor, Joseph C.;Sharon, Gil et al. (2023) Integrated Multi‐Cohort Analysis of the Parkinson's Disease Gut MetagenomeISSN 0885-3185
- Ousey, James;Boktor, Joseph C. et al. (2023) Gut microbiota suppress feeding induced by palatable foodsISSN 0960-9822PMCID PMC9839363
2022
- Boktor, Joseph C.;Adame, Mark D. et al. (2022) Global metabolic profiles in a non-human primate model of maternal immune activation: implications for neurodevelopmental disordersISSN 1359-4184PMCID PMC9772216
- Abdel-Haq, Reem;Schlachetzki, Johannes C. M. et al. (2022) A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing miceISSN 2050-084XPMCID PMC9668333
- Boktor, Joseph C.;Sharon, Gil et al. (2022) Integrated multi-cohort analysis of the Parkinson's disease gut metagenome
- Chen, Xinhong;Ravindra Kumar, Sripriya et al. (2022) Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systemsISSN 0896-6273PMCID PMC9308721
- Abdel-Haq, Reem;Schlachetzki, Johannes C. M. et al. (2022) A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice
- Bostick, John W.;Schonhoff, Aubrey M. et al. (2022) Gut microbiome-mediated regulation of neuroinflammationISSN 0952-7915PMCID PMC9167715
- Cryan, John F.;Mazmanian, Sarkis K. (2022) Microbiota–brain axis: Context and causalityISSN 0036-8075
- Schonhoff, Aubrey M.;Mazmanian, Sarkis K. (2022) Lung microbes mediate spinal-cord autoimmunityISSN 0028-0836
- Stewart Campbell, A.;Needham, Brittany D. et al. (2022) Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trialISSN 1078-8956
- Bostick, John W.;Mazmanian, Sarkis K. (2022) Impaired gut barrier affects microglia healthISSN 1097-6256
- Morton, James T.;Jin, Dong-Min et al. (2022) Multi-omic analysis along the gut-brain axis points to a functional architecture of autism
- Needham, Brittany D.;Funabashi, Masanori et al. (2022) A gut-derived metabolite alters brain activity and anxiety behaviour in miceISSN 0028-0836PMCID PMC9170029
2021
- Wu, Wei-Li;Adame, Mark D. et al. (2021) Microbiota regulate social behaviour via stress response neurons in the brainISSN 0028-0836PMCID PMC8346519
- Yoo, Bryan B.;Griffiths, Jessica A et al. (2021) Neuronal Activation of the Gastrointestinal Tract Shapes the Gut Environment in Mice
- Morais, Livia H.;Schreiber, Henry L., IV et al. (2021) The gut microbiota–brain axis in behaviour and brain disordersISSN 1740-1526
- Needham, Brittany D.;Adame, Mark D. et al. (2021) Plasma and Fecal Metabolite Profiles in Autism Spectrum DisorderISSN 0006-3223PMCID PMC7867605
- LaPelusa, Michael;Donoviel, Dorit et al. (2021) Microbiome for Mars: surveying microbiome connections to healthcare with implications for long-duration human spaceflight, virtual workshop, July 13, 2020ISSN 2049-2618PMCID PMC7781430
2020
- Needham, Brittany D.;Kaddurah-Daouk, Rima et al. (2020) Gut microbial molecules in behavioural and neurodegenerative conditionsISSN 1471-003X
- Schattgen, Stefan A.;Crawford, Jeremy C. et al. (2020) Intestinal intraepithelial lymphocyte repertoires are imprinted clonal structures selected for MHC reactivityISSN 0022-1767
- Donaldson, Gregory P.;Chou, Wen-Chi et al. (2020) Spatially distinct physiology of Bacteroides fragilis within the proximal colon of gnotobiotic miceISSN 2058-5276
- Quinn, Robert A.;Melnik, Alexey V. et al. (2020) Global chemical effects of the microbiome include new bile-acid conjugationsISSN 0028-0836
- Challis, Collin;Hori, Acacia et al. (2020) Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged miceISSN 1097-6256PMCID PMC7065967
- Sampson, Timothy R.;Challis, Collin et al. (2020) A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in miceISSN 2050-084XPMCID PMC7012599
2019
- Quinn, Robert A.;Thron, Taren et al. (2019) Chemical Impacts of the Microbiome Across Scales Reveal Novel Conjugated Bile Acids
- Pizarro, Theresa T.;Stappenbeck, Thaddeus S. et al. (2019) Challenges in IBD Research: Preclinical Human IBD MechanismsISSN 1078-0998
- Sharon, Gil;Cruz, Nikki Jamie et al. (2019) Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in MiceISSN 0092-8674PMCID PMC6993574
- Ramakrishna, Chandran;Kujawski, Maciej et al. (2019) Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitisISSN 2041-1723PMCID PMC6517419
- Abdel-Haq, Reem;Schlachetzki, Johannes C. M. et al. (2019) Microbiome–microglia connections via the gut–brain axisISSN 0022-1007PMCID PMC6314531
2018
- Griffiths, Jessica A.;Mazmanian, Sarkis K. (2018) Emerging evidence linking the gut microbiome to neurologic disordersISSN 1756-994XPMCID PMC6302417
- Schretter, Catherine E.;Vielmetter, Jost et al. (2018) A gut microbial factor modulates locomotor behavior in DrosophilaISSN 0028-0836PMCID PMC6237646
- Lee, Yun Kyung;Mehrabian, Parpi et al. (2018) The Protective Role of Bacteroides fragilis in a Murine Model of Colitis-Associated Colorectal CancerISSN 2379-5042PMCID PMC6236802
- Cekanaviciute, Egle;Pröbstel, Anne-Katrin et al. (2018) Multiple sclerosis-associated changes in the composition and immune functions of spore-forming bacteriaISSN 2379-5077PMCID PMC5690666
- Donaldson, G. P.;Ladinsky, M. S. et al. (2018) Gut microbiota utilize immunoglobulin A for mucosal colonizationISSN 0036-8075PMCID PMC5973787
- Schretter, Catherine E.;Mazmanian, Sarkis K. (2018) Cultivating a Relationship with Gut BacteriaISSN 1550-4131
2017
- Cekanaviciute, Egle;Yoo, Bryan B. et al. (2017) Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse modelsISSN 0027-8424PMCID PMC5635915
- Edelblum, Karen L.;Sharon, Gil et al. (2017) The microbiome activates CD4 T-cell-mediated immunity to compensate for increased intestinal permeabilityISSN 2352-345XPMCID PMC5540699
- Chan, Ken Y.;Jang, Min J. et al. (2017) Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systemsISSN 1097-6256PMCID PMC5529245
- Yoo, Bryan B.;Mazmanian, Sarkis K. (2017) The Enteric Network: Interactions between the Immune and Nervous Systems of the GutISSN 1074-7613PMCID PMC5551410
- Wu, Wei-Li;Hsiao, Elaine Y. et al. (2017) The Placental Interleukin-6 Signaling Controls Fetal Brain Development and BehaviorISSN 0889-1591PMCID PMC5373986
- Stone, Shannon;Shon, Judy et al. (2017) Cell-selective proteomic analysis of host-microbe interactions using Bio-orthogonal Noncanonical Amino Acid Tagging (BONCAT)
- Kollmann, Tobias R.;Kampmann, Beate et al. (2017) Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune OntogenyISSN 1074-7613
- Baranzini, Sergio E.;Cekanaviciute, Egle et al. (2017) The MS-Associated Gut MicrobiomeISSN 1352-4585
- Meisel, Marlies;Mayassi, Toufic et al. (2017) Interleukin-15 promotes intestinal dysbiosis with butyrate deficiency associated with increased susceptibility to colitisISSN 1751-7362PMCID PMC5315477
2016
- Lee, Cho-Rong;Kwak, Yewon et al. (2016) Myeloid-Derived Suppressor Cells Are Controlled by Regulatory T Cells via TGF-β during Murine ColitisISSN 2211-1247
- Mazmanian, Sarkis K.;Sampson, Timothy R. et al. (2016) Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's DiseaseISSN 0092-8674PMCID PMC5718049
- Sharon, Gil;Sampson, Timothy R. et al. (2016) The Central Nervous System and the Gut MicrobiomeISSN 0092-8674PMCID PMC5127403
- Neff, C. Preston;Rhodes, Matthew E. et al. (2016) Diverse Intestinal Bacteria Contain Putative Zwitterionic Capsular Polysaccharides with Anti-inflammatory PropertiesISSN 1931-3128PMCID PMC5113727
- Choi, Harry M. T.;Calvert, Colby R. et al. (2016) Mapping a multiplexed zoo of mRNA expressionISSN 0950-1991PMCID PMC5087610
- Casaccia, P.;Zhu, Y. et al. (2016) Effect of oral versus injectable disease-modifying therapies on the epigenome-wide DNA methylation and gut microbiota in multiple sclerosis patientsISSN 1352-4585
- Cekanaviciute, E.;Debelius, J. W. et al. (2016) Gut dysbiosis is a feature of MS and it is characterized by bacteria able to regulate lymphocyte differentiation in vitroISSN 1352-4585
- Chu, Huitung;Khosravi, Arya et al. (2016) Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel diseaseISSN 0036-8075PMCID PMC4996125
- Chandran, Ramakrishna;Liu, Hiutung et al. (2016) Immunomodulation of Host Immunity by Bacteriodes fragillis Polysaccharide A (PSA) Prevents Viral EncephalitisISSN 0022-1767
- Donaldson, Gregory P.;Lee, S. Melanie et al. (2016) Gut biogeography of the bacterial microbiotaISSN 1740-1526PMCID PMC4837114
2015
- Chu, Hiutung;Mazmanian, Sarkis K. (2015) Winning the Microbial Battle, but Not the WarISSN 0092-8674
- Yang, Yang;Wang, Chunlin et al. (2015) Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoiresISSN 2050-084XPMCID PMC4714975
- Cekanaviciute, E.;Runia, T. F. et al. (2015) The influence of microbiota on the adaptive immune response in MSISSN 1352-4585
- Sampson, Timothy R.;Mazmanian, Sarkis K. (2015) Control of Brain Development, Function and Behavior by the MicrobiomeISSN 1931-3128PMCID PMC4442490
- Yano, Jessica M.;Yu, Kristie et al. (2015) Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin BiosynthesisISSN 0092-8674PMCID PMC4393509
- Wu, Wei-Li;Hsiao, Elaine Y. et al. (2015) Maternal Immune Activation Perturbs Fetal Brain Development and Adult Behaviors Through Placental Trophoblast IL-6 ActivationISSN 0586-7614
2014
- Mayer, Emeran A.;Knight, Rob et al. (2014) Gut Microbes and the Brain: Paradigm Shift in NeuroscienceISSN 0270-6474PMCID PMC4228144
- Sharon, Gil;Garg, Neha et al. (2014) Specialized Metabolites from the Microbiome in Health and DiseaseISSN 1550-4131PMCID PMC4337795
- Stefka, Andrew T.;Feehley, Taylor et al. (2014) Commensal bacteria protect against food allergen sensitizationISSN 0027-8424PMCID PMC4246970
- Baranzini, S. E.;Katz-Sand, I. et al. (2014) The MS Microbiome Consortium (MSMC): an academic multi-disciplinary collaborative effort to elucidate the role of the gut microbiota in MSISSN 1352-4585
- Ravel, Jacques;Mazmanian, Sarkis K. (2014) Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013ISSN 2049-2618PMCID PMC4102747
- Dorrestein, Pieter C.;Mazmanian, Sarkis K. et al. (2014) Finding the Missing Links among Metabolites, Microbes, and the HostISSN 1074-7613PMCID PMC4503329
- Lee, Yun Kyung;Mazmanian, Sarkis K. (2014) Microbial Learning Lessons: SFB Educate the Immune SystemISSN 1074-7613
- Khosravi, Arya;Yáñez, Alberto et al. (2014) Gut Microbiota Promote Hematopoiesis to Control Bacterial InfectionISSN 1931-3128PMCID PMC4144825
- Mahdavi, Alborz;Szychowski, Janek et al. (2014) Identification of secreted bacterial proteins by noncanonical amino acid taggingISSN 0027-8424PMCID PMC3890788
2013
- Hsiao, Elaine Y.;McBride, Sara W. et al. (2013) Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental DisordersISSN 0092-8674PMCID PMC3897394
- Lee, S. Melanie;Donaldson, Gregory P. et al. (2013) Bacterial colonization factors control specificity and stability of the gut microbiotaISSN 0028-0836PMCID PMC3893107
- Chu, Hiutung;Mazmanian, Sarkis K. (2013) Innate immune recognition of the microbiota promotes host-microbial symbiosisISSN 1529-2908PMCID PMC4109969
- Feehley, Taylor;Stefka, Andrew et al. (2013) Commensal bacteria induce a barrier protective response to prevent sensitization to food allergensISSN 0022-1767
- Khosravi, Arya;Mazmanian, Sarkis K. (2013) Disruption of the gut microbiome as a risk factor for microbial infectionsISSN 1369-5274PMCID PMC5695238
- McFall-Ngai, Margaret;Hadfield, Michael G. et al. (2013) Animals in a bacterial world, a new imperative for the life sciencesISSN 0027-8424PMCID PMC3587249
- Rivas, Magali Noval;Burton, Oliver T. et al. (2013) A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxisISSN 0091-6749PMCID PMC3860814
2012
- Hsiao, Elaine Y.;McBride, Sara W. et al. (2012) Neuroimmune changes in a mouse model of the maternal infection risk factor for schizophrenia and autismISSN 0165-5728
- Hsiao, Elaine Y.;McBride, Sara W. et al. (2012) Gastrointestinal symptoms and probiotic treatment in a mouse model of an autism risk factorISSN 0165-5728
- Shen, Yue;Torchia, Maria Letizia Giardino et al. (2012) Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease ProtectionISSN 1931-3128PMCID PMC3895402
- Wingender, Gerhard;Stepniak, Dariusz et al. (2012) Intestinal Microbes Affect Phenotypes and Functions of Invariant Natural Killer T Cells in MiceISSN 0016-5085PMCID PMC3404247
- Mahdavi, Alborz;Mazmanian, Sarkis et al. (2012) Identifying Secreted Proteins by Non-canonical Amino Acid TaggingISSN 0961-8368
- Hsiao, Elaine Y.;McBride, Sara W. et al. (2012) Modeling an autism risk factor in mice leads to permanent immune dysregulationISSN 0027-8424PMCID PMC3411999
- Khosravi, Arya;Mazmanian, Sarkis K. (2012) Breathe easy: microbes protect from allergiesISSN 1078-8956PMCID PMC4122662
2011
- Huang, Julie Y.;Lee, S. Melanie et al. (2011) The human commensal Bacteroides fragilis binds intestinal mucinISSN 1075-9964PMCID PMC3163789
- Chow, Janet;Tang, Haiqing et al. (2011) Pathobionts of the gastrointestinal microbiota and inflammatory diseaseISSN 0952-7915PMCID PMC3426444
- Round, June L.;Lee, S. Melanie et al. (2011) The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human MicrobiotaISSN 0036-8075PMCID PMC3164325
- Lee, Yun Kyung;Menezes, Juscilene S. et al. (2011) Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitisISSN 0027-8424PMCID PMC3063590
2010
- Lee, Yun Kyung;Mazmanian, Sarkis K. (2010) Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?ISSN 0036-8075PMCID PMC3159383
- Round, June L.;Mazmanian, Sarkis K. (2010) Inducible Foxp3^+ regulatory T-cell development by a commensal bacterium of the intestinal microbiotaISSN 0027-8424PMCID PMC2901479
- Round, June L.;O'Connell, Ryan M. et al. (2010) Coordination of tolerogenic immune responses by the commensal microbiotaISSN 0896-8411PMCID PMC3155383
- Chow, Janet;Mazmanian, Sarkis K. (2010) A Pathobiont of the Microbiota Balances Host Colonization and Intestinal InflammationISSN 1931-3128PMCID PMC2859213
- Chow, Janet;Lee, S. Melanie et al. (2010) Host-Bacterial Symbiosis in Health and DiseaseISBN 978-0-12-381300-8PMCID PMC3152488
2009
- Mazmanian, Sarkis K. (2009) Gut Immune Balance Is as Easy as S-F-BISSN 1074-7613
- Mazmanian, Sarkis;McBride, Sarah (2009) The Microbial Health FactorISSN 0890-3670
- Round, June L.;Mazmanian, Sarkis K. (2009) The gut microbiota shapes intestinal immune responses during health and diseaseISSN 1474-1733PMCID PMC4095778
- Chow, Janet;Mazmanian, Sarkis K. (2009) Getting the bugs out of the immune system: do bacterial microbiota "fix" intestinal T cell responses?ISSN 1931-3128
2008
- Mazmanian, Sarkis K.;Round, June L. et al. (2008) A microbial symbiosis factor prevents intestinal inflammatory diseaseISSN 0028-0836
- Mazmanian, Sarkis K. (2008) Capsular polysaccharides of symbiotic bacteria modulate immune responses during experimental colitisISSN 0277-2116
- Liu, Cui Hua;Lee, S. Melanie et al. (2008) Regulation of surface architecture by symbiotic bacteria mediates host colonizationISSN 0027-8424PMCID PMC2268772
2007
- Garrett, Wendy S.;Lord, Graham M. et al. (2007) Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune SystemISSN 0092-8674PMCID PMC2169385
2006
- Mazmanian, Sarkis K.;Kasper, Dennis L. (2006) The love–hate relationship between bacterial polysaccharides and the host immune systemISSN 1474-1733
2005
- Mazmanian, Sarkis K.;Liu, Cui Hua et al. (2005) An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune SystemISSN 0092-8674
2004
- Zhang, Rongguang;Wu, Ruiying et al. (2004) Structures of Sortase B from Staphylococcus aureus and Bacillus anthracis Reveal Catalytic Amino Acid Triad in the Active SiteISSN 0969-2126PMCID PMC2792001
- Zong, Yinong;Mazmanian, Sarkis K. et al. (2004) The Structure of Sortase B, a Cysteine Transpeptidase that Tethers Surface Protein to the Staphylococcus aureus Cell WallISSN 0969-2126
2003
- Jonsson, Ing-Marie;Mazmanian, Sarkis K. et al. (2003) The role of Staphylococcus aureus sortase A and sortase B in murine arthritisISSN 1286-4579
- Mazmanian, Sarkis K.;Skaar, Eric P. et al. (2003) Passage of Heme-Iron Across the Envelope of Staphylococcus aureusISSN 0036-8075
2002
- Jonsson, Ing-Marie;Mazmanian, Sarkis K. et al. (2002) On the role of Staphylococcus aureus sortase and sortase-catalyzed surface protein anchoring in murine septic arthritisISSN 0022-1899
- Perry, Adrienne M.;Ton-That, Hung et al. (2002) Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus. III. Lipid II is an in vivo peptidoglycan substrate for sortase-catalyzed surface protein anchoringISSN 0021-9258
- Ton-That, Hung;Mazmanian, Sarkis K. et al. (2002) Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus: cysteine 184 and histidine 120 of sortase form a thiolate-imidazolium ion pair for catalysisISSN 0021-9258
- Mazmanian, Sarkis K.;Ton-That, Hung et al. (2002) An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesisISSN 0027-8424PMCID PMC122358
- Bierne, Hélène;Mazmanian, Sarkis K. et al. (2002) Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulenceISSN 0950-382X
2001
- Lee, Vincent T.;Mazmanian, Sarkis K. et al. (2001) A Program of Yersinia enterocolitica Type III Secretion Reactions Is Activated by Specific SignalsISSN 0021-9193PMCID PMC95371
- Mazmanian, Sarkis K.;Ton-That, Hung et al. (2001) Sortase-catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureusISSN 0950-382X
2000
- Mazmanian, Sarkis K.;Liu, Gwen et al. (2000) Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infectionsISSN 0027-8424PMCID PMC25859
- Ton-That, Hung;Mazmanian, Sarkis K. et al. (2000) Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus: sortase catalyzed in vitro transpeptidation reaction using LPXTG peptide and NH2-Gly3 substratesISSN 0021-9193
1999
- Ton-That, Hung;Liu, Gwen et al. (1999) Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motifISSN 0027-8424PMCID PMC22937
- Mazmanian, Sarkis K.;Liu, Gwen et al. (1999) Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell WallISSN 0036-8075