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The Microbiome Activates CD4 T-cell-mediated Immunity to Compensate for Increased Intestinal Permeability

Edelblum KL, Sharon G, Gurminder S, Odenwald MA, Sailer A, Cao S, Ravens S, Thomsen I, Bissati KE, McLeod R, Dong C, Gurbuxani S, Prinz I, Mazmanian SK, Turner JR.  Cellular and Molecular Gastroenterology and Hepatology. 2017 Jun. https://doi.org/10.1016/j.jcmgh.2017.06.001

 

The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut

Yoo BB and Mazmanian SK.  Cell Immunity. 2017 Jun. http://dx.doi.org/10.1016/j.immuni.2017.05.011 Review.

 

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

Sampson, TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, Challis C, Schretter CE, Rocha S, Gradinaru V, Chesselet M-F, Keshavarzian A, Shannon KM, Krajmalnik-Brown R, Wittung-Stafshede P, Knight R, Mazmanian SK.  Cell. 2016 Dec 1. doi: 10.1016/j.cell.2016.11.018

 

The Placental Interleukin-6 Signaling Controls Fetal Brain Development and Behavior

Wu WL, Hsiao EY, Yan Z, Mazmanian SK, Patterson PH.  Brain Behavior and Immunity. 2016 Nov 9. doi: 10.1016/j.bbi.2016.11.007

 

The Central Nervous System and the Gut Microbiome

Sharon G, Sampson TR, Geschwind DH, and Mazmanian SK.  Cell. 2016 Nov. https://doi.org/10.1016/j.cell.2016.10.027

 

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

Chu H, Khosravi A, Kusumawardhani IK, Kwon AHK, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan ST, Xavier RJ, Ernst PB, Green DR. McGovern DPB, Virgin HW, Mazmanian SK.  Science. 2016 May 5. doi: 10.1126/science.aad9948

  

Gut biogeography of the bacterial microbiota

Donaldson GP, Lee SM, Mazmanian SKNature Reviews Microbiology. 2015 Oct 26. doi: 10.1038/nrmicro3552. Review.

 

 Control of Brain Development, Function, and Behavior by the Microbiome

Sampson TR, Mazmanian SKCell Host Microbe. 2015 May 13;17(5):565-576. doi: 10.1016/j.chom.2015.04.011. Review.

 

Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis.

Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, Nagler CR, Ismagilov RF, Mazmanian SK, Hsiao EY. Cell. 2015 Apr 9;161(2):264-76. doi: 10.1016/j.cell.2015.02.047.

 

Maternal Immune Activation Perturbs Fetal Brain Development and Adult Behaviors Through Placental Trophoblast IL-6 Activation.

Wu W, Hsiao EY, Yan Z, Mazmanian SK, Patterson PH.  Schizophrenia Bulletin. 2015 Mar 1;41(supp 1):S1-S341. doi:10.1093/schbul/sbv010.

 

Specialized metabolites from the microbiome in health and disease.

Sharon G, Garg N, Debelius J, Knight R, Dorrestein PC, Mazmanian SK. Cell Metab2014 Nov 4;20(5):719-30. doi: 10.1016/j.cmet.2014.10.016. Epub 2014 Nov 4.

 

Gut microbes and the brain: paradigm shift in neuroscience.

Mayer EA, Knight R, Mazmanian SK, Cryan JF, Tillisch K. J Neurosci. 2014 Nov 12;34(46):15490-6. doi: 10.1523/JNEUROSCI.3299-14.2014. Review.

 

Commensal bacteria protect against food allergen sensitization.

Stefka AT, Feehley T, Tripathi P, Qiu J, McCoy K, Mazmanian SK, Tjota MY, Seo GY, Cao S, Theriault BR, Antonopoulos DA, Zhou L, Chang EB, Fu YX, Nagler CR. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13145-50. doi: 10.1073/pnas.1412008111. Epub 2014 Aug 25.

 

The MS Microbiome Consortium (MSMC): an academic multi-disciplinary collaborative effort to elucidate the role of the gut microbiota in MS.

Baranzini SE, Katz-Sand I, Mazmanian SK, Becosme Y, London J, Farber R, Kanner R, Gomez R, Cree BA, Knight R, Casaccia P. Multiple Sclerosis Journal. (2014) 20 (S1). p. 339. doi: 10.1177/1352458514547846

 

Finding the Missing Links among Metabolites, Microbes, and the Host.

Dorrestein PC, Mazmanian SK, Knight R.  Immunity. 2014 Jun 19;40(6):824-832. doi: 10.1016/j.immuni.2014.05.015. Review.

 

Microbial Learning Lessons: SFB Educate the Immune System.

Lee YK, Mazmanian SK. Immunity. 2014 Apr 17;40(4):457-9. doi: 10.1016/j.immuni.2014.04.002.

 

Gut microbiota promote hematopoiesis to control bacterial infection.

Khosravi A, Yáñez A, Price JG, Chow A, Merad M, Goodridge HS, Mazmanian SK. Cell Host Microbe. 2014 Mar 12;15(3):374-81. doi: 10.1016/j.chom.2014.02.006.

 

Identification of secreted bacterial proteins by noncanonical amino acid tagging.

Mahdavi A, Szychowski J, Ngo JT, Sweredoski MJ, Graham RL, Hess S, Schneewind O, Mazmanian SK, Tirrell DA. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):433-8. doi: 10.1073/pnas.1301740111. Epub 2013 Dec 17.

  

Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.

Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH,Mazmanian SK. Cell. 2013 Dec 19;155(7):1451-63. doi: 10.1016/j.cell.2013.11.024. Epub 2013 Dec 5.

 

Bacterial colonization factors control specificity and stability of the gut microbiota.

Lee SM, Donaldson GP, Mikulski Z, Boyajian S, Ley K, Mazmanian SK. Nature. 2013 Sep 19;501(7467):426-9. doi: 10.1038/nature12447. Epub 2013 Aug 18.

 

Innate immune recognition of the microbiota promotes host-microbial symbiosis.

Chu H, Mazmanian SK. Nature Immunology. 2013 Jul;14(7):668-75. doi: 10.1038/ni.2635. Review.

 

Disruption of the gut microbiome as a risk factor for microbial infections.

Khosravi A, Mazmanian SK. Curr Opin Microbiol. 2013 Apr;16(2):221-7. doi: 10.1016/j.mib.2013.03.009. Epub 2013 Apr 15. Review.

 

Animals in a bacterial world, a new imperative for the life sciences.

McFall-Ngai M, Hadfield MG, Bosch TC, Carey HV, Domazet-Lošo T, Douglas AE, Dubilier N, Eberl G, Fukami T, Gilbert SF, Hentschel U, King N, Kjelleberg S, Knoll AH, Kremer N, Mazmanian SK, Metcalf JL, Nealson K, Pierce NE, Rawls JF, Reid A, Ruby EG, Rumpho M, Sanders JG, Tautz D, Wernegreen JJ. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3229-36. doi: 10.1073/pnas.1218525110. Epub 2013 Feb 7. Review.

 

A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis.

Noval Rivas M, Burton OT, Wise P, Zhang YQ, Hobson SA, Garcia Lloret M, Chehoud C, Kuczynski J, DeSantis T, Warrington J, Hyde ER, Petrosino JF, Gerber GK, Bry L, Oettgen HC, Mazmanian SK, Chatila TA. J Allergy Clin Immunol. 2013 Jan;131(1):201-12. doi: 10.1016/j.jaci.2012.10.026. Epub 2012 Nov 30.

 

Outer membrane vesicles of a human commensal mediate immune regulation and disease protection.

Shen Y, Giardino Torchia ML, Lawson GW, Karp CL, Ashwell JD, Mazmanian SK. Cell Host Microbe. 2012 Oct 18;12(4):509-20. doi: 10.1016/j.chom.2012.08.004. Epub 2012 Sep 20.

 

Modeling an autism risk factor in mice leads to permanent immune dysregulation.

Hsiao EY, McBride SW, Chow J, Mazmanian SK, Patterson PH. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12776-81. doi: 10.1073/pnas.1202556109. Epub 2012 Jul 16.

 

Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice.

Wingender G, Stepniak D, Krebs P, Lin L, McBride S, Wei B, Braun J, Mazmanian SK, Kronenberg M. Gastroenterology. 2012 Aug;143(2):418-28. doi: 10.1053/j.gastro.2012.04.017. Epub 2012 Apr 19.

 

Breathe easy: microbes protect from allergies.

Khosravi A, Mazmanian SK. Nature Medicine2012 Apr 5;18(4):492-4. doi: 10.1038/nm.2723

 

Pathobionts of the gastrointestinal microbiota and inflammatory disease.

Chow J, Tang H, Mazmanian SK. Curr Opin Immunol. 2011 Aug;23(4):473-80. doi: 10.1016/j.coi.2011.07.010. Epub 2011 Aug 17. Review.

 

The human commensal Bacteroides fragilis binds intestinal mucin.

Huang JY, Lee SM, Mazmanian SK. Anaerobe. 2011 Aug;17(4):137-41. doi: 10.1016/j.anaerobe.2011.05.017. Epub 2011 Jun 2.

 

The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota.

Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, Mazmanian SK. Science. 2011 May 20;332(6032):974-7. doi: 10.1126/science.1206095. Epub 2011 Apr 21.

 

Has the microbiota played a critical role in the evolution of the adaptive immune system?

Lee YK, Mazmanian SK. Science. 2010 Dec 24;330(6012):1768-73. doi: 10.1126/science.1195568. Review.

 

Host-bacterial symbiosis in health and disease.

Chow J, Lee SM, Shen Y, Khosravi A, Mazmanian SK. Adv Immunol. 2010;107:243-74. doi: 10.1016/B978-0-12-381300-8.00008-3. Review.

 

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis.

Lee YK, Menezes JS, Umesaki Y, Mazmanian SK. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4615-22. doi: 10.1073/pnas.1000082107. Epub 2010 Jul 26.

 

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota.

Round JL, Mazmanian SK. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12204-9. doi: 10.1073/pnas.0909122107. Epub 2010 Jun 21.

 

A pathobiont of the microbiota balances host colonization and intestinal inflammation.

Chow J, Mazmanian SK. Cell Host Microbe. 2010 Apr 22;7(4):265-76. doi: 10.1016/j.chom.2010.03.004.

 

Coordination of tolerogenic immune responses by the commensal microbiota.

Round JL, O'Connell RM, Mazmanian SK. J Autoimmun. 2010 May;34(3):J220-5. doi: 10.1016/j.jaut.2009.11.007. Epub 2009 Dec 6. Review.

 

Gut immune balance is as easy as S-F-B.

Mazmanian SK. Immunity. 2009 Oct 16;31(4):536-8. doi: 10.1016/j.immuni.2009.09.005.

 

The gut microbiota shapes intestinal immune responses during health and disease.

Round JL, Mazmanian SK. Nat Rev Immunol. 2009 May;9(5):313-23. doi: 10.1038/nri2515. Review. Erratum in: Nat Rev Immunol. 2009 Aug;9(8):600.

 

Getting the bugs out of the immune system: do bacterial microbiota "fix" intestinal T cell responses?

Chow J, Mazmanian SK. Cell Host Microbe. 2009 Jan 22;5(1):8-12. doi: 10.1016/j.chom.2008.12.006.

 

A microbial symbiosis factor prevents intestinal inflammatory disease.

Mazmanian SK, Round JL, Kasper DL. Nature. 2008 May 29;453(7195):620-5. doi: 10.1038/nature07008.

 

Capsular polysaccharides of symbiotic bacteria modulate immune responses during experimental colitis.

Mazmanian SK. J Pediatr Gastroenterol Nutr. 2008 Apr;46 Suppl 1:E11-2. doi: 10.1097/01.mpg.0000313824.70971.a7. Review. No abstract available.

 

Regulation of surface architecture by symbiotic bacteria mediates host colonization.

Liu CH, Lee SM, Vanlare JM, Kasper DL, Mazmanian SK. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3951-6. doi: 10.1073/pnas.0709266105. Epub 2008 Mar 4.

 

Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system.

Garrett WS, Lord GM, Punit S, Lugo-Villarino G, Mazmanian SK, Ito S, Glickman JN, Glimcher LH. Cell2007 Oct 5;131(1):33-45.

 

The love-hate relationship between bacterial polysaccharides and the host immune system.

Mazmanian SK, Kasper DL. Nat Rev Immunol2006 Nov;6(11):849-58. Epub 2006 Oct 6. Review.

 

An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system.

Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. Cell. 2005 Jul 15;122(1):107-18.

 

Structures of sortase B from Staphylococcus aureus and Bacillus anthracis reveal catalytic amino acid triad in the active site.

Zhang R, Wu R, Joachimiak G, Mazmanian SK, Missiakas DM, Gornicki P, Schneewind O, Joachimiak A. Structure2004 Jul;12(7):1147-56.

 

The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall.

Zong Y, Mazmanian SK, Schneewind O, Narayana SV. Structure. 2004 Jan;12(1):105-12.

 

The role of Staphylococcus aureus sortase A and sortase B in murine arthritis.

Jonsson IM, Mazmanian SK, Schneewind O, Bremell T, Tarkowski A. Microbes Infect. 2003 Jul;5(9):775-80.

 

Passage of heme-iron across the envelope of Staphylococcus aureus.

Mazmanian SK, Skaar EP, Gaspar AH, Humayun M, Gornicki P, Jelenska J, Joachmiak A, Missiakas DM, Schneewind O. Science. 2003 Feb 7;299(5608):906-9.

 

On the role of Staphylococcus aureus sortase and sortase-catalyzed surface protein anchoring in murine septic arthritis.

Jonsson IM, Mazmanian SK, Schneewind O, Verdrengh M, Bremell T, Tarkowski A. J Infect Dis. 2002 May 15;185(10):1417-24. Epub 2002 Apr 22.

 

Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence.

Bierne H, Mazmanian SK, Trost M, Pucciarelli MG, Liu G, Dehoux P, Jänsch L, Garcia-del Portillo F, Schneewind O, Cossart P; European Listeria Genome Consortium. Mol Microbiol. 2002 Feb;43(4):869-81.

 

Anchoring of surface proteins to the cell wall of Staphylococcus aureus. III. Lipid II is an in vivo peptidoglycan substrate for sortase-catalyzed surface protein anchoring.

Perry AM, Ton-That H, Mazmanian SK, Schneewind O. J Biol Chem. 2002 May 3;277(18):16241-8. Epub 2002 Feb 20.

 

An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis.

Mazmanian SK, Ton-That H, Su K, Schneewind O. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2293-8. Epub 2002 Feb 5.

 

Anchoring of surface proteins to the cell wall of Staphylococcus aureus. Cysteine 184 and histidine 120 of sortase form a thiolate-imidazolium ion pair for catalysis.

Ton-That H, Mazmanian SK, Alksne L, Schneewind O. J Biol Chem. 2002 Mar 1;277(9):7447-52. Epub 2001 Nov 19.

 

A program of Yersinia enterocolitica type III secretion reactions is activated by specific signals.

Lee VT, Mazmanian SK, Schneewind O. J Bacteriol. 2001 Sep;183(17):4970-8.

 

Sortase-catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureus.

Mazmanian SK, Ton-That H, Schneewind O. Mol Microbiol. 2001 Jun;40(5):1049-57. Review.

 

Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections.

Mazmanian SK, Liu G, Jensen ER, Lenoy E, Schneewind O. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5510-5.

 

Anchoring of surface proteins to the cell wall of Staphylococcus aureus. Sortase catalyzed in vitro transpeptidation reaction using LPXTG peptide and NH(2)-Gly(3) substrates.

Ton-That H, Mazmanian SK, Faull KF, Schneewind O. J Biol Chem. 2000 Mar 31;275(13):9876-81.

 

Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif.

Ton-That H, Liu G, Mazmanian SK, Faull KF, Schneewind O. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12424-9.

 

Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall.

Mazmanian SK, Liu G, Ton-That H, Schneewind O. Science. 1999 Jul 30;285(5428):760-3.